Is There Really Any Link Between Vaping And COVID?

Is there really any link between vaping and COVID?  Most likely not, according the results of the largest study on the matter to date.  That study, done by the Mayo Clinic, found literally no correlation between vaping and being diagnosed with COVID.  And of course, the MSM was predictably crickets about that.

Not only that, they found that current combustible cigarette smokers were at a lower risk of contracting the virus.  That latter finding is rather puzzling until you consider something a bit esoteric that is frequently pointed out by Dr. Dmitry Kats:  some of the nicotine in tobacco, upon combustion (and also in the liver to a degree), turns into nicotinic acid, better known as Niacin (Vitamin B3) which he notes seems to really work wonders in curing and preventing COVID.  To achieve this same benefit without putting one's lungs in jeopardy, it would be better to simply take niacin directly, at least 500 mg at a time, along with cofactors Vitamin C (which gets depleted by smoking), Vitamin D, zinc, quercetin, thiamine (which also gets blocked by nicotine), B-12, magnesium, selenium, melatonin, and the amino acid lysine.  

So why did a previous smaller study seem to find that (younger) vapers were more likely to get COVID than non-vapers?  Well, smaller sample size can magnify any biases and confounders in a study, and one obvious bias is that younger vapers often share devices, which can clearly spread the virus.  They may also be more likely to attend parties that can turn into superspreader events.  But the act of vaping itself, while not exactly the healthiest habit in the world, does not appear to be directly causally linked to an increased risk of contracting the disease. 

Interestingly, even that previous smaller study of teens and young adults only found a correlation with "ever used" vape products, but NO correlation with recent use.  That is a rather strange finding for a study that purports to show a causal link to vaping.

As for the theory that people who got that mysterious vaping illness EVALI in 2019 and early 2020 were at greater risk of COVID later on, that may very well be true.  But we know now that it was primarily the result of black market THC (i.e. cannabis) vape products adulterated with questionable additives, most notably Vitamin E acetate.  And it is very telling that states where cannabis was legal for recreational sale in 2019 saw not only fewer per capita cases of EVALI than states where it was not, but also fewer COVID deaths as well.  Ditto for countries where cannabis was and still is fully legal (Canada, Uruguay) as well as where it is de facto legal (Netherlands) compared to their neighbors where it was not.  Thus, the lingering subtle lung damage from using tainted vapes several months prior may very well increase one's susceptibility to severe and fatal COVID, meaning that the cannabis prohibitionists whose policies created these black markets may have even way more blood on their hands than we thought.

But legal and untainted vape products, whether nicotine, cannabis, or otherwise?  The evidence that they significantly increase the risk of COVID simply isn't there, period.  Another myth bites the dust.

The No-Brainer Solution To The College Question (2021 Edition)

Last August, Twenty-One Debunked had argued that colleges and universities should reopen with minimal restrictions for the most part.  And guess what, we still do, with even fewer restrictions still.  

This time around, that means:

No vaccine mandates or "passports" for anyone 

No mask mandates for anyone 

No testing mandates, except perhaps a rapid test for students upon initial arrival on campus and before and after long holiday breaks, as well as perhaps for certain employees 

No quarantines for anyone unless testing positive and/or showing symptoms 

No prison-like rules or conditions 

No six-foot antisocial distancing rules (at least not outside the classroom)

No public or private gathering bans (ok, maybe a Rule of 500 if you really wanna be anal about it)

No closures or class cancellations lasting more than a few days, if even that

No kicking students out of dorms en masse to be sent home to infect their parents/grandparents 

All classes in-person full-time (unless students choose otherwise)

100% capacity 

PERIOD

And, of course, lower the drinking age to 18, along with the smoking and toking age too.  Or at the very least, treat it as such de facto if not officially.

Let America Be America Again!

'Nuff said

UPDATE 1:  The Tweet below is precisely what we do NOT want to see.  EVER AGAIN.

Ironically, their neighbor "Zoo Mass" sounds like LESS of a zoo in comparison.  As for K-12 schools, once again Sweden still has the right idea overall:

I mean, Team Reality has only been saying exactly this for the past 18 months, right?

UPDATE 2:  As of the end of September, it looks like many if not most colleges in the USA, from state schools all the way to Ivy League schools are NOT heeding our advice one bit.  Even ones with a 100% vaccination rate (!) due to mandates seem to have the craziest rules that would make Orwell himself blush!  These overpriced gilded cage wannabe prisons need to be boycotted at once, as that is the only way to get them to stop this insanity for good.  Honestly, if you can't find a college that offers even a near-normal college experience after 18 months of this madness, perhaps you should take a gap year (or two or three as the case may be) until you can find one.

Another New Study Confirms: Legalizing Cannabis Not A Disaster After All

Yet another study confirms what we have known all along:  legalization of recreational cannabis was NOT a disaster after all.  The study found that legalization at the state level was NOT associated with any increases in drug treatment admissions, violent crime, or overdose deaths, and in some cases even appeared to have the opposite effect.  These findings dovetail with other recent studies as well, and we are really not surprised.  So much for the gateway drug theory, Reefer Madness, and other tired, old perennial Chicken Little predictions from the prohibitionists.

Additionally, just days earlier, another tired, old myth bit the dust as well.  Another new study finds no link between cannabis use and the stereotypical "amotivational syndrome" after controlling for confounders.  This particular study followed 14-17 year olds for a period of two years and did not find such a correlation, which is notable since numerous previous studies of the matter have generally failed to find such effects in adults but occasionally succeeded when looking specifically at adolescents.  So the fact that they could not detect such effects in that age group implies that such effects, if they do occur, are relatively rare and most likely confined to the small minority of very-heavy and ultra-heavy users and/or those who began using cannabis even earlier in life still.  And it thoroughly puts the lie to the fearmongers' claim that legalization would supposedly result in a nation of "orange-lipped couch-potato" zombies whose only semblance of motivation is the acquisition of their next hit.

And yet another myth debunked as well:  cannabis use does NOT appear to be independently linked to increased risk of stroke in young adults after adjusting for confounders such as tobacco use, according to another new study.  While previous studies on the matter have yielded inconsistent results, the prohibitionists of course luuurrrrved to spin such studies to their advantage.

Thus, no good reason not to fully legalize cannabis for everyone over 18 nationwide yesterday, and treat it no more stringently than alcohol or tobacco.  Period.

To anyone reading this who still opposes legalization, because reasons, we have a question for you: How does it feel to be on the wrong side of history?  Because we wouldn't know anything about that.

Have A Safe And Happy Memorial Day Weekend

This coming Monday, May 31, is Memorial Day, often known as the unofficial first day of summer and National BBQ Day.  But let's remember what it really is--a day to honor all of the men and women of our armed forces who made the ultimate sacrifice for our country, past and present.  And that of course includes all of those who died serving our country before they were legally old enough to drink.  Let us all take a moment of silence to honor them.

As for Candy Lightner, the ageist turncoat founder of MADD who had the chutzpah and hubris to go on national TV in 2008 and publicly insult our troops, may her name and memory be forever blotted out. 

And as always, arrive alive, don't drink and drive.  It's just not worth it, period.  And it's very simple to prevent.  If you plan to drive, don't drink, and if you plan to drink, don't drive.  It's not rocket science.   Designate a sober driver, call a cab or rideshare, crash on the couch, or even walk if you have to.  Or don't drink--nobody's got a gun to your head.

"No Safe Level" Is A Red Flag For Junk Science

According to a wise man named Paracelsus (essentially the Western world's first toxicologist) long ago, it is the dose that makes the poison.  Anything (even water) can be poisonous in a high enough quantity, and conversely there is, practically speaking, a safe level for everything.  It is all a matter of degree.  So why, when it comes to things like alcohol, do the "experts" seem to lose all common sense?

Take the latest study of alcohol and the brain at Oxford, for example.  This one claims that there is no safe level of alcohol for the brain, that is, any amount will cause damage.  The observational study, which notably has not even been peer-reviewed yet, finds a negative linear correlation between alcohol drinking volume and the volume of gray matter (as well as white matter) in brain scans, even after controlling for every confounder they could think of.  While it is known that excessive drinking can damage the brain, the shocker here seems to have more to do with much lower levels of drinking previously thought to be safe.

I bet the reader can quickly spot the problem here.  If not, here it goes.  A closer look at the data shows that, given how small the overall effect size is, with alcohol explaining only 0.8% of the variance in gray matter, combined with the tendency of people (especially heavier drinkers) to undercount their drinks, the apparent harmful effects of light to moderate drinking may very well be spurious at the lower end of the curve even if likely genuine towards the higher end.  That, and the lack of peer review of course.

They also found an additive effect of "binge" drinking over and above the effect of drinking volume alone, particularly for daily "binging", which was fairly strong and consistently statistically significant.  But given the rather wide confidence intervals, for less than daily "binge" drinking, it was not always statistically significant.  Given the typically fairly low definitions used for "binge" drinking, it would not be surprising that the confidence intervals are so wide.

It also appears from this study that people with hypertension (high blood pressure) and/or a high BMI are significantly more sensitive to the apparent adverse effects of alcohol than the average person for whatever reasons as well.  The interaction was not just additive, but multiplicative.  That will certainly require further study going forward. 

We are not in any way encouraging anyone to drink alcoholic beverages. But specious inferences should not cloud the issue either.

There is a safe level everything, even arsenic apparently.  So why would that not be true for alcohol?  Especially since our own bodies can actually produce a bit of it as a byproduct, believe it or not?

On the bright side, at least the study looked largely at older adults (age 40+) and did not indulge in the usual youth drinking panic routines.  Even if the observed effects are 100% true, that would of course mean that young people are not uniquely vulnerable to the adverse effects of alcohol on the brain.

25, You Say? Let's Nip That In The Bud

A handful of psychiatrists in Minnestota, where cannabis has not yet been legalized for recreational use (but is currently being considered), is calling for the age limit to be 25 when it is legalized.  They cite anecdotal evidence of young patients with psychosis that they claim is caused by today's high-potency weed.  And here is why they are, in a word, wrong:

1. First of all, these psychoses that they cite are occurring despite recreational cannabis remaining illegal in Minnesota for all ages.  Legalizing it with an utterly unrealistic age limit of 25 will only preserve and entrench the current black market while worsening criminal justice inequities, both age and racial disparities.
2. The brain continues developing well into the 30s and 40s, and the risk period for schizophrenia continues until about 30, so 25 is arbitrary.
3. While excessive cannabis use can be harmful at any age, and starting use before age 18 and especially before 15 is likely more harmful than starting at 18 or older, there is really no clear and convincing evidence that using it at 18-20 is any worse than using at 21-24 or 25+, especially for light or moderate use.  To claim otherwise is unscientific, disingenuous, and really pushes the limits of the precautionary principle.
4. As we have noted many times before, the relationship between cannabis and psychosis is quite complex, and far more nuanced than Reefer Madness.  Though there is likely a tiny, exquisitely vulnerable sliver of the population that should really avoid weed like the plague at any age, that is no reason for blanket bans or restrictions (by age or otherwise) for legal adults.  That would be unscientific and unjust.
5. And finally, if today's high-potency weed is in fact the culprit in an alleged (and far from certain) recent increase in psychosis among young people, the solution is NOT to raise the age limit and force it deeper underground, but to put a cap (say, 10% or 15%) on the potency of THC on legal weed (and perhaps also setting a minimum level of CBD, which counteracts many of the adverse effects of too much THC), and/or taxing it based on THC/CBD levels.  And also warn people who are at increased risk of psychosis as well via honest public education messaging without sensational fearmongering.

There it is.  Problem solved.  No good reason to set the age limit any higher than 18, let alone 25.  Let's nip this ageist idea in the bud, pun intended of course.

UPDATE:  Twenty-One Debunked believes that proper labeling and tax incentives alone will likely be enough to encourage lower THC and higher CBD levels even in the absence of hard THC/CBD limits.  Taxing cannabis at a higher rate base on THC levels (whether proportionally, or perhaps disproportionally when exceeding a specific threshold or for specific product categories) and applying an offsetting tax discount based on CBD levels would do the trick, as the market would adjust accordingly.

Also, getting back to the subject of psychosis in young people, don't forget to take your fish oil.  Yes, you read that right.  Apparently a new study found that there is an inverse correlation between omega-3 fatty acid levels during adolescence and psychosis in young adulthood.  This dovetails nicely with a study from 2010 that found that just 12 weeks of giving fish oil supplements to teens at ultra-high risk of psychosis greatly reduced their risk of developing psychosis a year later compared with those given placebo.

Latest California Smoking Age Study More Smoke Than Fire

Last month, a new study looking at the results of California's smoking age hike from 18 to 21 in 2016 turns out to be less than meets the eye.  The study, looking at BRFSS survey data for 18-20 year olds pre versus post implementation, found that, compared to 21-23 year olds in California and to 18-20 year olds in the eight comparison states, 18-20 year olds did not see any significant change in the rate of decline of current or ever smoking, but did see significantly faster declines in the rates of daily smoking in the three years after the age limit was hiked to 21 versus before implementation.  Interestingly, vaping was not examined at all due to apparent data gaps at the time, so this study says absolutely nothing about vaping.

While the part about daily smoking sounds impressive on the surface, one should keep in mind that cigarette taxes were hiked by $2.00/pack in 2016 (effective April 2017), and generally the younger a person is, the more price-sensitive they are since they tend to have less disposable income, and furthermore the earlier they are in the course of their tobacco habits.  So it would stand to reason that the tax hike alone, which makes regular and especially daily smoking that much more of an expensive burden on the smoker, would have had a larger impact on 18-20 year olds than 21-23 year olds in California.  That would also explain why current or ever smoking (which were essentially not affected at all) would be much less affected than daily smoking as well.  

Of note, Pennsylvania had also raised their cigarette tax in 2016 yet still kept their age limit at 18 (until July 2020, that is), yet interestingly that state was NOT one of the eight comparison states.  The results of this study would thus likely have been very different if Pennsylvania was one of the comparison states.

Alternatively, some of the progression to daily smoking may simply have been delayed by a few years by the age limit hike, yielding no real long-run benefits, kinda like some studies have strongly suggested about drunk driving deaths when the drinking age was raised to 21.  Indeed, by 2019 the daily smoking rate among 21-23 year olds was actually a bit higher than it was in 2016.

And as we have previously noted, in NYC and elsewhere, raising the smoking age to 21 does not seem to actually reduce high school smoking rates compared with keeping it 18, so the "trickle-down" theory that is often used as a specious justification for Tobacco 21 laws is very unlikely to be the case in California (or anywhere else) either.

Thus, this study is more smoke than fire.  And regardless, we at Twenty-One Debunked would still oppose the 21 smoking age on principle regardless of its effects.  Young adults who are old enough to go to war, be tried as adults, etc. should NOT have the state dictating what otherwise legal substances they choose to put into their own bodies at all, period.  Seriously.

And that is a hill we will die on.

Et Tu, DeSantis?

Florida's controversial Governor Ron DeSantis (R) has been a bit of a mixed bag overall.  The True Spirit of America Party (TSAP) is, to put it mildly, not exactly a fan of Republicans in general and Trump supporters in particular, but has nonetheless generally agreed with his light-touch, focused protection handling of the COVID-19 pandemic, which has actually yielded a lower cumulative per capita death rate than the national average (and much lower than several lockdown states) despite Florida's significantly older and fatter population.  And in terms of excess all-cause mortality, wide-open Florida even did better than the overall strictest state of all, California.  There are some bad things about DeSantis of course, such as his latest Georgia-style voter suppression efforts and his heavy-handed and poorly-written anti-rioting law that arguably throws out the proverbial baby with the bathwater, but generally he is not too terrible by current low-bar Republican standards.

And of course, Twenty-One Debunked in particular has supported the fact that he was one of the most prominent holdouts in keeping the legal smoking age at 18 despite the trend towards raising it to 21 at the local, state, and eventually federal levels.  After all, he has previously opposed and vetoed every single attempt to raise Florida's smoking age any higher than 18.  Well, until now, that is.  Like most other governors, as of today, DeSantis has officially SOLD OUT and signed into law a bill that raises Florida's smoking and vaping age to 21, effective October 1, 2021.  True, this new law does have an exemption for military service members aged 18-20, making it a shade less bad than some other states, but we still oppose this law on principle like we oppose all inherently ageist Tobacco 21 laws, period.

One could argue that any state law that sets the age limit below 21 is effectively void since the federal smoking age has been 21 since December 2019, but that is beside the point.  A state that chooses to remain 18 in spite of the federal Tobacco 21 law is a principled state with integrity, and is at the very least NOT helping the federal government enforce such an ageist abomination.  Today, Florida lost that status.

DeSantis is now the 34th governor to raise the age limit for tobacco and vaping to 21, bringing it to now more than two out of three states who set it at 21.  With "allies" like him (and Trump, who raised the federal age limit to 21), who really needs enemies?

NEWS FLASH: Vaping Black Market Concoctions Is Bad For Your Lungs

That is what the conclusion should have been from the latest vaping study finding that cannabis vaping is more harmful to the lungs than nicotine vaping, cannabis smoking, and tobacco smoking.  But that does not appear to be the way the mainstream media is presenting the study, without any sort of nuance or detail.  The study did not distinguish between black market, gray market, and legitimate market products, nor did it bother to examine or even mention the old-fashioned way of vaping weed (namely heating regular and pure whole bud in a loose-leaf vaporizer).

Have we really forgotten the primary culprit in the EVALI (vaping illness) epidemic in 2019, namely questionable additives and diluents such as Vitamin E acetate (et al.) that were almost entirely found in black and gray market cannabis vape oil concoctions?  Especially since EVALI was significantly less common in states where cannabis is fully legal compared to states where it is not, as there are by definition much safer alternatives to the black market in legal states (though a significant black market still remains in highly taxed and tightly regulated states like California as well, or at least did in 2019-2020).

The solution is really quite simple:  legalize cannabis 18+, ban any additives that have not been proven safe for human consumption via inhalation, implement strict quality control standards, don't overtax it, charge excessive licensing fees, or otherwise have excessive barriers to entry into the legitimate market, and crack down on any remaining illicit markets.

And for users, as we have said before, DO NOT vape, juul, or dab anything you find on the black market!

Problem solved.  We ignore these facts at our peril.

What About Tobacco, Again?

The Biden administration is currently considering two new sweeping FDA rules affecting combustible tobacco cigarettes:  1) banning menthol cigarettes and flavored cigars, and 2) reducing nicotine levels, presumably to a non-addictive level.  Where we stand on these two potential changes is as follows:

The first one, Twenty-One Debunked is on the fence about that, as we can see both sides of that issue, noting that Canada has already banned menthols and the EU has phased them out, while also noting the inconvenient truth of racism and how it intersects with this issue as well.   The flavored cigars we generally lean against banning, while for menthol cigarettes we believe that if they must do it for whatever reason, they should phase them out more gradually and allow existing stocks to be sold well after the designated "quit date" for selling newly manufactured menthols.  Also, possession and consumption of menthols should NOT be banned or punished, and police should NOT go out of their way to target the sale of menthols or "loosies" in underprivileged neighborhoods with people of color.

(For what it's worth, quit rates in Canada have improved significantly since their menthol ban, particularly among formerly menthol-preferring smokers.  That lends credence to the idea that menthol enhances the overall addictiveness of tobacco by making the high nicotine levels less harsh on the throat, which also makes it easier for young experimenters to pick up the habit in the first place.)

The second one, reducing nicotine levels, Twenty-One Debunked has cautiously supported since 2014, and we still do, provided that all of the following are true:

• The phasedown of nicotine to a non-addictive level is done gradually and stepwise over a period of at least a year, in at least three stages.
• The sale of existing domestic stocks of cigarettes above the nicotine cap can continue at least six months after the "quit date" for manufacturing and importing cigarettes above that cap (at each step of the phasedown).  
• The possession/consumption of cigarettes with nicotine levels above the cap is NOT banned or punished.
• The only other tobacco products subject to the same cap shall be little cigars (below a certain size), perhaps all cigars with a smoke pH below 8, and possibly loose roll-your-own cigarette tobacco and/or pipe tobacco with a pH below 8.  Nothing else, period.  We would be fine with, and would actually prefer, if only pre-rolled commercial cigarettes and little cigars (the size of cigarettes) were subject to the nicotine cap.  
• The addition of any harmful or addictive additives to all newly manufactured tobacco products is banned effective immediately as well.  All additives must meet the same standards as for additives to food.  Radioactive fertilizers for growing tobacco must also be banned as well.

While the effectiveness of the flavor ban is a bit questionable at best, the nicotine cap and phasedown would likely greatly reduce the prevalence of tobacco smoking and associated disease and death, simply by making this conveniently deadly product by design far less addictive.  More people would quit fairly quickly, and fewer people would take up the habit in the first place.  And people who miss the old high-nicotine smokes of yore would still be free to use alternative tobacco and nicotine products.

And doing it gradually enough will make it so there is no more of a black market for higher-nicotine cigarettes than there is for incandescent light bulbs.

As for vaping, Twenty-One Debunked does not support such a massive reduction in nicotine levels to that proposed for combustible cigarettes, but rather we support reducing the nicotine content in vape products to the maximum levels permitted in the EU, UK, and Israel.  That would nix the super-addictive ones that notoriously get young people hooked within seven days (JUUL, we're looking at you!) while still allowing plenty of nicotine for adult vapers who are trying to quit smoking.  (Twenty-One Debunked does NOT recommend anyone take up vaping, except as a last-ditch effort for truly hardened and refractory adult smokers who cannot quit any other way.)

Of course, we also think the smoking age should be lowered back to 18, just like we feel about the drinking age and toking age.  We are not called Twenty-One Debunked for nothing, after all.  Raising the age limit to 21 was at best useless, and is an ageist abomination.  In the meantime, though, the above is our nuanced and well-thought-out stance on the latest tobacco-related measures being proposed. 

FINAL THOUGHT:  By the way, the fact that they use the "think of the children!" argument to justify the banning of menthols and flavored cigars, is really just a tacit admission that raising the smoking age to 21 was essentially useless in keeping cigarettes and cigars from "trickling down" to people under 18.