"No Safe Level" Is A Red Flag For Junk Science

According to a wise man named Paracelsus (essentially the Western world's first toxicologist) long ago, it is the dose that makes the poison.  Anything (even water) can be poisonous in a high enough quantity, and conversely there is, practically speaking, a safe level for everything.  It is all a matter of degree.  So why, when it comes to things like alcohol, do the "experts" seem to lose all common sense?

Take the latest study of alcohol and the brain at Oxford, for example.  This one claims that there is no safe level of alcohol for the brain, that is, any amount will cause damage.  The observational study, which notably has not even been peer-reviewed yet, finds a negative linear correlation between alcohol drinking volume and the volume of gray matter (as well as white matter) in brain scans, even after controlling for every confounder they could think of.  While it is known that excessive drinking can damage the brain, the shocker here seems to have more to do with much lower levels of drinking previously thought to be safe.

I bet the reader can quickly spot the problem here.  If not, here it goes.  A closer look at the data shows that, given how small the overall effect size is, with alcohol explaining only 0.8% of the variance in gray matter, combined with the tendency of people (especially heavier drinkers) to undercount their drinks, the apparent harmful effects of light to moderate drinking may very well be spurious at the lower end of the curve even if likely genuine towards the higher end.  That, and the lack of peer review of course.

They also found an additive effect of "binge" drinking over and above the effect of drinking volume alone, particularly for daily "binging", which was fairly strong and consistently statistically significant.  But given the rather wide confidence intervals, for less than daily "binge" drinking, it was not always statistically significant.  Given the typically fairly low definitions used for "binge" drinking, it would not be surprising that the confidence intervals are so wide.

It also appears from this study that people with hypertension (high blood pressure) and/or a high BMI are significantly more sensitive to the apparent adverse effects of alcohol than the average person for whatever reasons as well.  The interaction was not just additive, but multiplicative.  That will certainly require further study going forward. 

We are not in any way encouraging anyone to drink alcoholic beverages. But specious inferences should not cloud the issue either.

There is a safe level everything, even arsenic apparently.  So why would that not be true for alcohol?  Especially since our own bodies can actually produce a bit of it as a byproduct, believe it or not?

On the bright side, at least the study looked largely at older adults (age 40+) and did not indulge in the usual youth drinking panic routines.  Even if the observed effects are 100% true, that would of course mean that young people are not uniquely vulnerable to the adverse effects of alcohol on the brain.